Check Intently (2)pentobarbital will decrease the level or influence of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Powerful CYP3A4 inducers may lower suvorexant efficacy; if increased suvorexant dose demanded, tend not to exceed twenty mg/working daypentobarbital will lessen the level or impact of diltia